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Can I read IL-10 enhances cell-to-cell communication in chondrocytes via STAT3 signaling pathway on EtoBox?
IL-10 enhances cell-to-cell communication in chondrocytes via STAT3 signaling pathway by Daimo Guo; Shiyi Kan; Li Zhang; Zhixing Niu; Mengmeng Duan; Yang Liu; Xiaohua Pu; Mingru Bai; Caixia Pi; Demao Zhang; Chenchen Zhou; Jing Xie is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is IL-10 enhances cell-to-cell communication in chondrocytes via STAT3 signaling pathway about?
Gap junction intercellular communication (GJIC) allows the transfer of material, message and energy between cells, which influences cell behaviors including cell proliferation, migration, differentiation and apoptosis and determines cell fate. Interleukin-10 (IL-10), a versatile cytokine, attracts more and more attention in the cartilage pathology such as osteoarthritis (OA) due to its potential in anti-inflammation and wound repair. However, whether IL-10 can mediate GJIC in chondrocytes remains elusive. In the current study, we aimed to explore the role of IL-10 on GJIC and its underlying mechanism. We found that IL-10 can promote GJIC in living chondrocytes. IL-10-enhanced GJIC in chondrocytes was dependent on the up-regulation of connexin 43 (Cx43). Knockdown experiment based on siRNA interference then confirmed that IL-10-enhanced GJIC required participation of IL-10 receptor 1 (IL-10R1). IL-10 activated signal transducer and activator of transcription 3 (STAT3) signaling and promoted the nuclear accumulation of p-STAT3 through IL-10 receptor 1. Inhibitor experiment further confirmed the importance of STAT3 signaling in IL-10-mediated GJIC. Taking together, our results provide
Who reads IL-10 enhances cell-to-cell communication in chondrocytes via STAT3 signaling pathway?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Daimo Guo; Shiyi Kan; Li Zhang; Zhixing Niu; Mengmeng Duan; Yang Liu; Xiaohua Pu; Mingru Bai; Caixia Pi; Demao Zhang; Chenchen Zhou; Jing Xie
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)