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Can I read Lipolysis-derived Linoleic Acid Drives Beige Fat Progenitor Cell Proliferation on EtoBox?
Lipolysis-derived Linoleic Acid Drives Beige Fat Progenitor Cell Proliferation by Ichitaro Abe; Yasuo Oguri; Anthony R.P. Verkerke; Lauar B. Monteiro; Carly M. Knuth; Christopher Auger; Yunping Qiu; Gregory P. Westcott; Saverio Cinti; Kosaku Shinoda; Marc G. Jeschke; Shingo Kajimura is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Lipolysis-derived Linoleic Acid Drives Beige Fat Progenitor Cell Proliferation about?
De novo beige adipocyte biogenesis involves the proliferation of progenitor cells in white adipose tissue (WAT); however, what regulates this process remains unclear. Here, we report that in mouse models but also in human tissues, WAT lipolysis-derived linoleic acid triggers beige progenitor cell proliferation following cold acclimation, β3-adrenoceptor activation, and burn injury. A subset of adipocyte progenitors, as marked by cell surface markers PDGFRα or Sca1 and CD81, harbored cristae-rich mitochondria and actively imported linoleic acid via a fatty acid transporter CD36. Linoleic acid not only was oxidized as fuel in the mitochondria but also was utilized for the synthesis of arachidonic acid-derived signaling entities such as prostaglandin D2. Oral supplementation of linoleic acid was sufficient to stimulate beige progenitor cell proliferation, even under thermoneutral conditions, in a CD36-dependent manner. Together, this study provides mechanistic insights into how diverse pathophysiological stimuli, such as cold and burn injury, promote de novo beige fat biogenesis.
Who reads Lipolysis-derived Linoleic Acid Drives Beige Fat Progenitor Cell Proliferation?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ichitaro Abe; Yasuo Oguri; Anthony R.P. Verkerke; Lauar B. Monteiro; Carly M. Knuth; Christopher Auger; Yunping Qiu; Gregory P. Westcott; Saverio Cinti; Kosaku Shinoda; Marc G. Jeschke; Shingo Kajimura
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)