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Can I read Condensation and protamination of sperm chromatin affect ICSI outcomes when gametes from healthy individuals are used on EtoBox?
Condensation and protamination of sperm chromatin affect ICSI outcomes when gametes from healthy individuals are used by Jordi Ribas-Maynou; Sergi Novo; Albert Salas-Huetos; Sergi Rovira; Marta Antich; Marc Yeste is a Medicine article available to read on EtoBox.
What is Condensation and protamination of sperm chromatin affect ICSI outcomes when gametes from healthy individuals are used about?
## Abstract ## STUDY QUESTION Do defects in sperm chromatin protamination and condensation have an impact on ICSI outcomes? ## SUMMARY ANSWER Sperm protamination is related to fertilization rates in healthy donors, and the in vitro capacity of sperm to condense their chromatin is linked to blastocyst rates, both associations being more apparent in women <33 years of age. ## WHAT IS KNOWN ALREADY Previous data on how sperm chromatin damage affects ICSI outcomes are inconsistent. Revealing which sperm factors influence embryo development is necessary to understand the male contribution to ICSI success and to develop novel sperm selection techniques or male-based treatments. Sperm chromatin is mainly condensed in protamines, which are cross-linked through disulphide bridges. This study aimed to determine whether sperm protamination and the integrity of disulphide bonds (condensation) are related to embryo development after ICSI. ## STUDY DESIGN, SIZE, DURATION The design was a retrospective study with a blind analysis of sperm chromatin. Gametes were divided into two groups: double donation (DD) cohort and single donation (SD) cohort. Samples from 45 semen donors used in 55 ICSI cycle
Who reads Condensation and protamination of sperm chromatin affect ICSI outcomes when gametes from healthy individuals are used?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Jordi Ribas-Maynou; Sergi Novo; Albert Salas-Huetos; Sergi Rovira; Marta Antich; Marc Yeste
- Publisher
- Oxford University Press (OUP)
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)