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Can I read Strategies to Therapeutically Modulate Cytokine Action on EtoBox?
Strategies to Therapeutically Modulate Cytokine Action by Warren J. Leonard; Jian-Xin Lin is a Medicine article available to read on EtoBox.
What is Strategies to Therapeutically Modulate Cytokine Action about?
Cytokines are secreted or membrane-presented molecules that mediate broad cellular functions, including development, differentiation, growth and survival. Accordingly, the regulation of cytokine activity is extraordinarily important both physiologically and pathologically. Cytokine and/or cytokine receptor engineering is being widely investigated to safely and effectively modulate cytokine activity for therapeutic benefit. IL-2 in particular has been extensively engineered, to create IL-2 variants that differentially exhibit activities on regulatory T cells to potentially treat autoimmune disease versus effector T cells to augment antitumour effects. Additionally, engineering approaches are being applied to many other cytokines such as IL-10, interferons and IL-1 family cytokines, given their immunosuppressive and/or antiviral and anticancer effects. In modulating the actions of cytokines, the strategies used have been broad, including altering affinities of cytokines for their receptors, prolonging cytokine half-lives in vivo and fine-tuning cytokine actions. The field is rapidly expanding, with extensive efforts to create improved therapeutics for a range of diseases. Nature Revi
Who reads Strategies to Therapeutically Modulate Cytokine Action?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Warren J. Leonard; Jian-Xin Lin
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)