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Downstream targets of Nm23-H1: Gene expression profiling of CAL 27 cells using DNA microarray by Maja Herak Bosnar; Ružica Bago; Koraljka Gall-Trošelj; Thomas Streichert; Jasminka Pavelić is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract The human __nm23‐H1__ was discovered as a tumor metastasis suppressor based on its reduced expression in melanoma cell lines with low versus high metastatic potential. It encodes for one of two subunits of the nucleoside‐diphosphate kinase. Besides its role in the maintenance of the cells NTP pool, __nm23__ plays a key role in different cellular processes. The role of __nm23‐H1__ in these processes still has to be elucidated. Our goal was to identify Nm23‐H1 downstream targets by subjecting Nm23‐H1 overexpressing CAL 27 cells oral squamous cell carcinoma (OSSC) to microarray analysis. The genes with changed expression patterns could be clustered into several groups: transforming growth factor β (TGFβ) signaling pathway, cell adhesion, invasion and motility, proteasome machinery, cell‐cycle, epithelial structural and related molecules and others. Based on the expression patterns observed we presume that __nm23‐H1__ might have a role in OSSCs, which should be confirmed by future experiments. © 2006 Wiley‐Liss, Inc.

Who reads Downstream targets of Nm23-H1: Gene expression profiling of CAL 27 cells using DNA microarray?

Author

Maja Herak Bosnar; Ružica Bago; Koraljka Gall-Trošelj; Thomas Streichert; Jasminka Pavelić

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-1987)

Published

2006

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)