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Influence of ionic conditions on knotting in a coarse-grained model for DNA by Wettermann, Sarah; Datta, Ranajay; Virnau, Peter is a scholarly article available to read on EtoBox.

What is Influence of ionic conditions on knotting in a coarse-grained model for DNA about?

We investigate knotting probabilities of long double-stranded DNA strands in a coarse-grained Kratky-Porod model for DNA with Monte Carlo simulations. Various ionic conditions are implemented by adjusting the effective diameter of monomers. We find that the occurrence of knots in DNA can be reinforced considerably by high salt conditions and confinement between plates. Likewise, knots can almost be dissolved completely in a low salt scenario. Comparisons with recent experiments confirm that the coarse-grained model is able to capture and quantitatively predict topological features of DNA and can be used for guiding future experiments on DNA knots.

Author

Wettermann, Sarah; Datta, Ranajay; Virnau, Peter

Published

2022

Language

EN