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Minimal Clinically Important Difference in Barthel Index Dyspnea in Patients with COPD by Michele Vitacca; Alberto Malovini; Bruno Balbi; Maria Aliani; Serena Cirio; Antonio Spanevello; Claudio Fracchia; Mauro Maniscalco; Giacomo Corica; Nicolino Ambrosino; Mara Paneroni is a Medicine article available to read on EtoBox.

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## Background The Barthel Index dyspnea (BId) is responsive to physiological changes and pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD). However, the minimum clinically important difference (MCID) has not been established yet. ## Aim To identify the MCID of BId in patients with COPD stratified according to the presence of chronic respiratory failure (CRF) or not. ## Materials and Methods Using the Medical Research Council (MRC) score as an anchor, receiver operating characteristic curves and quantile regression were retrospectively evaluated before and after pulmonary rehabilitation in 2327 patients with COPD (1151 of them with CRF). ## Results The median post-rehabilitation changes in BId for all patients were −10 (interquartile range = −17 to −3, p<0.001), correlating significantly with changes in MRC (r = 0.57, 95% CI = 0.53 to 0.59, p<0.001). Comparing different methods of assessment, the MCID ranged from −6.5 to −9 points for patients without and −7.5 to −12 points for patients with CRF. ## Conclusion The most conservative estimate of the MCID is −9 points in patients with COPD, without and −12 in those with CRF. This estimate may be use

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Author

Michele Vitacca; Alberto Malovini; Bruno Balbi; Maria Aliani; Serena Cirio; Antonio Spanevello; Claudio Fracchia; Mauro Maniscalco; Giacomo Corica; Nicolino Ambrosino; Mara Paneroni

Publisher

Dove Press Ltd.; Dove Medical Press; Dove Medical Press Ltd; Informa UK Limited; Dove Medical Press Ltd. (ISSN 1178-2005)

Published

2020

Language

EN

Field

Medicine (Health Sciences)