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Carcinoembryonic antigenic activity of tissue extracts: A quantitative study of malignant and benign neoplasms, cirrhotic liver, normal adult and fetal organs by S. K. Khoo; N. L. Warner; J. T. Lie; I. R. Mackay is a Medicine article available to read on EtoBox.

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## Abstract A quantitative study of carcinoembryonic antigenic activity (CEA) in extracts of 44 tumors, 42 fetal and 36 non‐malignant adult tissues from various organs was made and the CEA content detected by microradioimmunoassay was related to the wet tissue weight. A variety of malignant neoplasms, including carcinomas, sarcoma and Hodgkin's disease, contained CEA (range 17 to 2727 ng); apart from gastrointestinal carcinomas which had the highest content of CEA (230–2727 ng/g) only carcinomas of the lung contained moderate amounts of CEA (63–950 ng/g). The amount of CEA in extracts of fetal and normal adult organs was mostly low or not detectable except in the gastrointestinal tract and pancreas where it ranged from 65 to 200 ng/g in the fetus, and 28 to 86 ng/g in the adult. Differences in mean content of CEA between normal and cirrhotic livers were not significant. Although our results indicated that CEA was present in varying amounts in a variety of tumors the identification of these reactive substances will require more precise physico‐chemical and antigenic characterization.

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Author

S. K. Khoo; N. L. Warner; J. T. Lie; I. R. Mackay

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1973

Language

EN

Field

Medicine (Health Sciences)