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Can I read Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors on EtoBox?
Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors by Mei Liu; Zhili Xin; Jill E. Clampit; Sanyi Wang; Rebecca J. Gum; Deanna L. Haasch; James M. Trevillyan; Cele Abad-Zapatero; Elizabeth H. Fry; Hing L. Sham; Gang Liu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors about?
A novel class of 1,9-dihydro-9-hydroxypyrazolo [3,4-b]quinolin-4-ones as c-Jun-N-terminal kinase (JNK) inhibitors is described. These compounds were synthesized via the condensation of 2-nitrobenzaldehydes and hydroxypyrazoles. The structure-activity relationships (SAR) and kinase selectivity profile of the inhibitors are also discussed. Compound 16 was identified as a potent JNK inhibitor with good cellular potency.
Who reads Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Mei Liu; Zhili Xin; Jill E. Clampit; Sanyi Wang; Rebecca J. Gum; Deanna L. Haasch; James M. Trevillyan; Cele Abad-Zapatero; Elizabeth H. Fry; Hing L. Sham; Gang Liu
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2006
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)