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Novel Treatments for Metastatic Renal Cell Carcinoma by D.J. van Spronsen; P.F.A. Mulders; P.H.M. De Mulder is a Medicine article available to read on EtoBox.

What is Novel Treatments for Metastatic Renal Cell Carcinoma about?

The mainstay of any curative treatment in renal cell carcinoma (RCC) is surgery. In case of metastatic disease at presentation a radical nephrectomy is recommended to good performance status patients prior to start of interferon-alfa treatment. Interferon-alpha (IFN-alpha) offers in a small but significant percentage of patients advantage in overall survival; interleukin-2 (IL-2) based therapy gives similar survival rates. To date hormonal and chemotherapy do not have a proven impact on survival. The recent new insights in the molecular biology of clear RCC has revealed a key-role for vascular endothelial growth factor (VEGF) in the stimulation of angiogenesis in this highly vascularized tumour. This opens interesting new treatment strategies including: blockage of VEGF with the monoclonal antibody bevacizumab and inhibition of VEGF receptor tyrosine kinases (with small oral molecules such as SU11248 or PTK787). Likewise, inhibition of the Raf kinase pathway (with oral Bay 43-9006) or inhibition of the mTOR pathway (with i.v. CCI-779) are under investigation. Preliminary clinical results with all these compounds are interesting and the results of ongoing phase III studies will beco

Who reads Novel Treatments for Metastatic Renal Cell Carcinoma?

Author

D.J. van Spronsen; P.F.A. Mulders; P.H.M. De Mulder

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1040-8428)

Published

2005

Language

EN

Field

Medicine (Health Sciences)