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The Receptor SIGIRR Suppresses Th17 Cell Proliferation via Inhibition of the Interleukin-1 Receptor Pathway and mTOR Kinase Activation by Muhammet F. Gulen; Zizhen Kang; Katarzyna Bulek; Wan Youzhong; Tae Whan Kim; Yi Chen; Cengiz Z. Altuntas; Kristian Sass Bak-Jensen; Mandy J. McGeachy; Jeong-Su Do; Hui Xiao; Greg M. Delgoffe; Booki Min; Jonathan D. Powell; Vincent K. Tuohy; Daniel J. Cua; Xiaoxia Li is a Immunology and Microbiology article available to read on EtoBox.
What is The Receptor SIGIRR Suppresses Th17 Cell Proliferation via Inhibition of the Interleukin-1 Receptor Pathway and mTOR Kinase Activation about?
Interleukin-1 (IL-1)-mediated signaling in T cells is essential for T helper 17 (Th17) cell differentiation. We showed here that SIGIRR, a negative regulator of IL-1 receptor and Toll-like receptor signaling, was induced during Th17 cell lineage commitment and governed Th17 cell differentiation and expansion through its inhibitory effects on IL-1 signaling. The absence of SIGIRR in T cells resulted in increased Th17 cell polarization in vivo upon myelin oligodendrocyte glycoprotein (MOG 35-55 ) peptide immunization. Recombinant IL-1 promoted a marked increase in the proliferation of SIGIRR-deficient T cells under an in vitro Th17 cell-polarization condition. Importantly, we detected increased IL-1-induced phosphorylation of JNK and mTOR kinase in SIGIRRdeficient Th17 cells compared to wild-type Th17 cells. IL-1-induced proliferation was abolished in mTOR-deficient Th17 cells, indicating the essential role of mTOR activation. Our results demonstrate an important mechanism by which SIGIRR controls Th17 cell expansion and effector function through the IL-1-induced mTOR signaling pathway.
Who reads The Receptor SIGIRR Suppresses Th17 Cell Proliferation via Inhibition of the Interleukin-1 Receptor Pathway and mTOR Kinase Activation?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Muhammet F. Gulen; Zizhen Kang; Katarzyna Bulek; Wan Youzhong; Tae Whan Kim; Yi Chen; Cengiz Z. Altuntas; Kristian Sass Bak-Jensen; Mandy J. McGeachy; Jeong-Su Do; Hui Xiao; Greg M. Delgoffe; Booki Min; Jonathan D. Powell; Vincent K. Tuohy; Daniel J. Cua; Xiaoxia Li
- Publisher
- Elsevier Science; Elsevier ; Cell Press; Elsevier BV (ISSN 1074-7613)
- Published
- 2010
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)