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Can I read The Effect of Infliximab Dose Escalation in Inflammatory Bowel Disease Patients with Antibodies to Infliximab on EtoBox?
The Effect of Infliximab Dose Escalation in Inflammatory Bowel Disease Patients with Antibodies to Infliximab by Gloria S.Z. Tun; Kerry Robinson; Laura Marshall; Alison Wright; Laura Thompson; Graeme Wild; Ravishankar Sargur; Alenka J. Brooks; Melissa F. Hale; Thean S. Chew; Alan J. Lobo is a Medicine article available to read on EtoBox.
What is The Effect of Infliximab Dose Escalation in Inflammatory Bowel Disease Patients with Antibodies to Infliximab about?
## Background: Infliximab dose escalation (de) can be used in inflammatory bowel disease patient; however, the long-term benefit remains unclear, especially in those with antibodies to infliximab (ati). the aim was to assess the effect of de in patients with ati on drug level, clinical response and ati status. ## Methods: All patients undergoing infliximab de (a reduction in dose interval between infusions 10 au/ml, de significantly increased drug levels: median infliximab levels of 1.4 and 0.9 at baseline, respectively, to 3.2 and 3.5 at week 24. after de, 21/35 ati-positive patients had a fall in ati ≤10 au/ml. at week 24 following de 62/92 patients were in clinical remission. duration of clinical remission was shorter in those with ati >10 au/ml (median 24 weeks, range 0-88) than in those with transient/ati ≤10 au/ml (median 36 weeks, range 0-126, p = 0.06). ## Conclusions: A strategy of de for selected patients receiving infliximab is associated with an increase in drug levels and reduced ati positivity. this is associated with clinical remission in approximately 70% of patients at 6 months.
Who reads The Effect of Infliximab Dose Escalation in Inflammatory Bowel Disease Patients with Antibodies to Infliximab?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Gloria S.Z. Tun; Kerry Robinson; Laura Marshall; Alison Wright; Laura Thompson; Graeme Wild; Ravishankar Sargur; Alenka J. Brooks; Melissa F. Hale; Thean S. Chew; Alan J. Lobo
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)