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Duration of Mucositis and Dysphagia following Radiotherapy (+ Cetuximab) for Locoregionally Advanced Head and Neck Cancer by J.A. Bonner; P.M. Harari; J. Giralt; D. Raben; J. Jassem; N. Azarnia; S.A. Spencer; E.K. Rowinsky; N. Amellal; J.L. Baselga; K. Ang is a Medicine article available to read on EtoBox.

What is Duration of Mucositis and Dysphagia following Radiotherapy (+ Cetuximab) for Locoregionally Advanced Head and Neck Cancer about?

Objective: To determine expression, mutations, and effects on motility of the receptor tyrosine kinase c-MET in head and neck squamous cell carcinoma (HNSCC) and evaluate c-MET inhibition with SU11274/siRNA. Methods and Materials: A total of 128 HNSCC, dysplastic, and normal tissues (using immunohistochemistry) and 10 HNSCC cell lines (using immunoblot) were evaluated for c-MET, phospho-c-MET, and hepatocyte growth factor (HGF). In five cell lines, c-MET was inhibited using SU11274/small interfering RNA (siRNA)/PF-02341066. Effects on signaling (immunoblotting), viability (MTT/Cyquant), and motility (time-lapse video) were determined. Mutational analysis of HNSCC tumor tissue samples (n = 54) and cell lines (n = 12) was done. Results: Eighty-four (66%) HNSCC tumor samples overexpressed c-MET/phospho-c-MET pY1003 (dysplasia, n = 30 [64%]). Normal tissue had the lowest rate of overexpression (n = 21 [23%]). pY1230/1234/1235 overexpression was less prominent. Cytoplasmic HGF expression was seen. All cell lines showed c-MET expression. Five HNSCC cell lines were treated with SU11274. Phospho-tyrosine immunoblots showed SU11274 dose-dependent effects. Specifically, SU11274 led to inhibi

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Author

J.A. Bonner; P.M. Harari; J. Giralt; D. Raben; J. Jassem; N. Azarnia; S.A. Spencer; E.K. Rowinsky; N. Amellal; J.L. Baselga; K. Ang

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2007

Language

EN

Field

Medicine (Health Sciences)