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Gene expression changes induced by the human carcinogen aristolochic acid I in renal and hepatic tissue of mice by Volker M. Arlt; Jie Zuo; Kristina Trenz; Candice A. Roufosse; Graham M. Lord; Joelle L. Nortier; Heinz H. Schmeiser; Monica Hollstein; David H. Phillips is a Medicine article available to read on EtoBox.
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## Abstract Aristolochic acid (AA) is the causative agent of urothelial tumors associated with AA nephropathy and is also implicated in the development of Balkan endemic nephropathy‐associated urothelial tumors. These tumors contain AA‐characteristic __TP53__ mutations. We examined gene expression changes in Hupki (human __TP53__ knock‐in) mice after treatment with aristolochic acid I (AAI) by gavage (5 mg/kg body weight). After 3, 12 and 21 days of treatment gene expression profiles were investigated using Agilent Whole Mouse 44K Genome Oligo Array. Expression profiles were significantly altered by AAI treatment in both target (kidney) and nontarget (liver) tissue. Renal pathology and DNA adduct analysis confirmed kidney as the target tissue of AAI‐induced toxicity. Gene ontology for functional analysis revealed that processes related to apoptosis, cell cycle, stress response, immune system, inflammatory response and kidney development were altered in kidney. Canonical pathway analysis indicated Nfκb, aryl hydrocarbon receptor, Tp53 and cell cycle signaling as the most important pathways modulated in kidney. Expression of __Nfκb1__ and other Nfκb‐target genes was confirmed by quan
Who reads Gene expression changes induced by the human carcinogen aristolochic acid I in renal and hepatic tissue of mice?
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- Author
- Volker M. Arlt; Jie Zuo; Kristina Trenz; Candice A. Roufosse; Graham M. Lord; Joelle L. Nortier; Heinz H. Schmeiser; Monica Hollstein; David H. Phillips
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)