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Gene amplification as a mechanism of reversion at the HPRT locus in V79 chinese hamster cells by Olga Zownir; James C. Fuscoe; Raymond Fenwick; John Morrow is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Gene amplification as a mechanism of reversion at the HPRT locus in V79 chinese hamster cells about?

Spontaneous phenotypic revertants of hypoxanthine phosphoribosyl-transferase (HPRT) temperature-sensitive V79 Chinese hamster cells were selected by plating a temperature-sensitive mutant in HAT medium at 39OC. The incidence of such revertants was approximately 2 x per cell. The majority of the revertants examined had increases of between three-and tenfold in their specific activity of the enzyme, and they were able to grow continuously

Who reads Gene amplification as a mechanism of reversion at the HPRT locus in V79 chinese hamster cells?

Author

Olga Zownir; James C. Fuscoe; Raymond Fenwick; John Morrow

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)

Published

1984

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)