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Motility of Efferent Duct Cilia Aids Passage of Sperm Cells Through the Male Reproductive System by Isabella Aprea; Tabea Nöthe-Menchen; Gerard W Dougherty; Johanna Raidt; Niki T Loges; Thomas Kaiser; Julia Wallmeier; Heike Olbrich; Timo Strünker; Sabine Kliesch; Petra Pennekamp; Heymut Omran is a Medicine article available to read on EtoBox.
What is Motility of Efferent Duct Cilia Aids Passage of Sperm Cells Through the Male Reproductive System about?
## Abstract Motile cilia line the efferent ducts of the mammalian male reproductive tract. Several recent mouse studies have demonstrated that a reduced generation of multiple motile cilia in efferent ducts is associated with obstructive oligozoospermia and fertility issues. However, the sole impact of efferent duct cilia dysmotility on male infertility has not been studied so far either in mice or human. Using video microscopy, histological- and ultrastructural analyses, we examined male reproductive tracts of mice deficient for the axonemal motor protein DNAH5: this defect exclusively disrupts the outer dynein arm (ODA) composition of motile cilia but not the ODA composition and motility of sperm flagella. These mice have immotile efferent duct cilia that lack ODAs, which are essential for ciliary beat generation. Furthermore, they show accumulation of sperm in the efferent duct. Notably, the ultrastructure and motility of sperm from these males are unaffected. Likewise, human individuals with loss-of-function __DNAH5__ mutations present with reduced sperm count in the ejaculate (oligozoospermia) and dilatations of the epididymal head but normal sperm motility, similar to DNAH5 d
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- Author
- Isabella Aprea; Tabea Nöthe-Menchen; Gerard W Dougherty; Johanna Raidt; Niki T Loges; Thomas Kaiser; Julia Wallmeier; Heike Olbrich; Timo Strünker; Sabine Kliesch; Petra Pennekamp; Heymut Omran
- Publisher
- Oxford University Press (OUP)
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)