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Locoregional Recurrence in Patients with Anastomotic Leakage After Anterior Resection for Rectal Carcinoma by S. Merkel; W. Y. Wang; O. Schmidt; O. Dworak; CH. Wittekind; W. Hohenberger; P. Hermanek is a Medicine article available to read on EtoBox.

What is Locoregional Recurrence in Patients with Anastomotic Leakage After Anterior Resection for Rectal Carcinoma about?

## Objective Anastomotic leakage is a serious complication after anterior resection for rectal carcinoma. It is controversial whether anastomotic leakage influences the rate of locoregional recurrence and therefore survival. ## Patients and methods The data of 940 patients with invasive rectal carcinoma stage I–III treated by curative anterior resection from 1978 to 1996 at the Department of Surgery of the University of Erlangen were analysed. Patients who received neoadjuvant or adjuvant treatment were excluded as well as patients who died postoperatively. 89 out of 814 patients (10.9%) developed an anastomotic leakage after anterior resection. ## Results The rate of locoregional recurrence during the first five postoperative years of all patients was 13.6%. In patients with anastomotic leakage the rate of locoregional recurrence was 22.0%, significantly higher than in patients without anastomotic leakage which was 12.5%, (__P__=0.018). On multivariate Cox regression analysis anastomotic leakage was shown to be an independent risk factor for locoregional recurrence (relative risk: 1.7, CI 95%: 1.02–2.75, __P__=0.042). Also cancer‐related survival was influenced significantly by an

Who reads Locoregional Recurrence in Patients with Anastomotic Leakage After Anterior Resection for Rectal Carcinoma?

Author

S. Merkel; W. Y. Wang; O. Schmidt; O. Dworak; CH. Wittekind; W. Hohenberger; P. Hermanek

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1462-8910)

Published

2001

Language

EN

Field

Medicine (Health Sciences)