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Antioxidant activity of curcumin protects against the radiation-induced micronuclei formation in cultured human peripheral blood lymphocytes exposed to various doses of γ-Radiation by Ganesh Chandra Jagetia is a Medicine article available to read on EtoBox.

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## Purpose: Ionizing radiations trigger the formation of free radicals that damage dna and cause cell death. dna damage may be simply evaluated by micronucleus assay and the pharmacophores that impede free radicals could effectively reduce the dna damage initiated by irradiation. therefore, it was desired to determine the capacity of curcumin to alleviate micronuclei formation in human peripheral blood lymphocytes (hpbls) exposed to 0-4 gy of γ-radiation. ## Materials and methods: Hpbls were exposed to 3 gy after 30 minutes of 0.125, 0.25, 0.5, 1, 2, 5, 10, 20 or 50 μg/ml curcumin treatment or with 0.5 μg/ml curcumin 30 minutes early to 0, 0.5, 1, 2, 3 or 4 gy co γ-irradiation. cytokinesis of hpbls was blocked by cytochalasin b and micronuclei scored. the ability of curcumin to suppress free radical induction in vitro was determined by standard methods. ## Results: Hpbls treated with different concentrations of curcumin before 3 gy irradiation alleviated the micronuclei formation depending on curcumin concentration and the lowest micronuclei were detected at 0.5 μg/ml curcumin when compared to 3 gy irradiation alone. increasing curcumin concentration caused a gradual rise in micron

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Author

Ganesh Chandra Jagetia

Publisher

Informa UK Limited

Published

2021

Language

EN

Field

Medicine (Health Sciences)