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Can I read Achillea Millefolium Alleviates Testicular Damage in Paclitaxel‐intoxicated Rats via Attenuation of Testicular Oxido‐inflammatory Stress and Apoptotic Responses on EtoBox?
Achillea Millefolium Alleviates Testicular Damage in Paclitaxel‐intoxicated Rats via Attenuation of Testicular Oxido‐inflammatory Stress and Apoptotic Responses by Ufuk Okkay; Irmak Ferah Okkay; Betul Cicek; Ismail Cagri Aydin; Muhammed Sait Ertugrul; Cemil Bayram; Selcuk Senyayla; Selma Sezen; Ali Sefa Mendil; Leyla Guven; Ahmet Hacimuftuoglu is a Medicine article available to read on EtoBox.
What is Achillea Millefolium Alleviates Testicular Damage in Paclitaxel‐intoxicated Rats via Attenuation of Testicular Oxido‐inflammatory Stress and Apoptotic Responses about?
The aim of this study was to investigate the effects of Achillea millefolium extract in paclitaxel-induced testicular toxicity in rats. The groups were designed as (1) control, (2) paclitaxel (8 mg/kg, intraperitoneally), (3) paclitaxel (8 mg/kg, intraperitoneally) + Achillea millefolium (200 mg/kg, orally for 14 consecutive days) and (4) paclitaxel (8 mg/kg, intraperitoneally) + Achillea millefolium (400 mg/kg, orally for 14 consecutive days). Serum levels of testosterone, luteinising hormone and follicle-stimulating hormone, as well as total antioxidant capacity and total oxidant status were measured one day after receiving the last dose of Achillea millefolium extract. Testicular superoxide dismutase activity, malondialdehyde, tumour necrosis factor alpha and interleukin-1β levels, the expressions of nuclear factor kappa B and caspase-3 were evaluated. In addition, testicular sections were evaluated histopathologically and 8-hydroxy-2'-deoxyguanosine was detected immunohistochemically. Achillea millefolium improved the levels of luteinising hormone, follicle-stimulating hormone and testosterone, upregulated testicular antioxidant enzymes and downregulated inflammation. Furthermo
Who reads Achillea Millefolium Alleviates Testicular Damage in Paclitaxel‐intoxicated Rats via Attenuation of Testicular Oxido‐inflammatory Stress and Apoptotic Responses?
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- Author
- Ufuk Okkay; Irmak Ferah Okkay; Betul Cicek; Ismail Cagri Aydin; Muhammed Sait Ertugrul; Cemil Bayram; Selcuk Senyayla; Selma Sezen; Ali Sefa Mendil; Leyla Guven; Ahmet Hacimuftuoglu
- Publisher
- Hindawi Limited
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)