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The study identifies the Smc5/6 complex as a host restriction factor that inhibits transcription of extrachromosomal DNA, including the hepatitis B virus (HBV) genome. The hepatitis B virus X protein (HBx) hijacks the cellular DDB1-containing E3 ubiquitin ligase to target the Smc5/6 complex for degradation, thereby enhancing HBV transcription. This novel mechanism reveals how HBx promotes viral gene expression by relieving transcriptional inhibition imposed by the Smc5/6 complex.

Author

rudolf.beran

Language

EN