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## Vildagliptin Bullous pemphigoid: case report An 82-year-old woman developed bullous pemphigoid during treatment with vildagliptin for type 2 diabetes [route and dosage not stated]. The woman presented with itchy eruptions on the head and on upper extremities for 8 months. It was also reported that, she had been receiving vildagliptin and concomitant glimepiride for type 2 diabetes. She had started receiving vildagliptin 18 months before the presentation. At the current presentation, a physical examination revealed small bullae on her upper extremities and back. A biopsy revealed a subepidermal blister, which was predominantly infiltrated with eosinophils. A direct immunofluorescence on perilesional skin revealed linear IgG, IgA and C3 protein deposits. Indirect immunofluorescence on the normal skin revealed IgG positivity at the epidermal basement membrane zone, and IgG and IgA positivity on the epidermal side of 1 mol/L salt-split skin. Immunoblot analysis with different proteins revealed IgG reactivity to BP180NC16a with only skin involvement. Further investigation revealed BP180 positivity. An IgA ELISA test revealed BP180 and BP230 negativity. Subsequently, she was diagnosed

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Publisher

Adis International Limited (now part of Wolters Kluwer Health); Springer-Verlag; Springer Science and Business Media LLC (ISSN 0114-9954)

Published

2018

Language

EN

Field

Medicine (Health Sciences)