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Synthesis and Mechanistic Study of Steroidal Oxime Ethers by Kamlesh Sharma; Shivani B. Mishra; Ajay K. Mishra is a Chemistry article available to read on EtoBox.

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## Abstract Reaction of 5__α__‐cholestan‐6‐one oxime (**1**), its 3__β__‐acetoxy and 3__β__‐chloro analogs, **2** and **3**, respectiveley, with ClCH~2~CH~2~NH~2~⋅HCl in presence of MeONa afforded 6‐[(2‐aminoethoxy)imino]‐5__α__‐cholestane (**4**), 3__β__‐acetoxy‐6‐[(2‐aminoethoxy)imino]‐5__α__‐cholestane (**5**), and 6‐[(2‐aminoethoxy)imino]‐3__β__‐chloro‐5__α__‐cholestane (**6**), respectively. The structures of newly synthesized compounds have been established on the basis of physical, analytical, and spectral data. Theoretical calculations were assessed by using DFT at B3LYP/6‐31G\* level to describe the mechanism of the reaction. The stability and feasibility of all the generated structures studied in this report were supported by their respective fundamental frequencies and energy minima.

Who reads Synthesis and Mechanistic Study of Steroidal Oxime Ethers?

Author

Kamlesh Sharma; Shivani B. Mishra; Ajay K. Mishra

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0018-019X)

Published

2011

Language

EN

Field

Chemistry (Physical Sciences)