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1. Inhibition of the renin-angiotensin system with ACE inhibitors, ARBs, or ARNIs in conjunction with evidence-based beta blockers and aldosterone antagonists is recommended for patients with chronic HFrEF to reduce morbidity and mortality. 2. Neprilysin breaks down vasoactive peptides like natriuretic peptides. Inhibition of neprilysin potentiates their action but angiotensin II is also broken down, requiring co-administration with RAAS blockade. 3. Sacubitril/valsartan is an ARNI that is an alternative

Author

Zaky prasetya

Language

EN