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This study investigates the kinetics of C-trifluoromethylation of aniline using various S-(trifluoromethyl) salts, revealing that the heterocyclic salt exhibits higher reactivity due to enhanced activation entropy. The findings suggest that the reaction mechanism is not a conventional S_N2 attack but rather involves a side-on attack to the CF3-S bond. The results highlight the unique properties of trifluoromethylating agents and their potential applications in organic synthesis.
- Author
- 6ensanderson
- Language
- EN