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YKL-40 as a novel biomarker related to white matter damage and cognitive impairment in patients with cerebral small vessel disease by Wei Zhang; Xia Zhou; Jiabin Yin; Wenming Zhao; Chaojuan Huang; Cun Zhang; Ke Wan; Mingxu Li; Xiaoqun Zhu; Zhongwu Sun is a Neuroscience article available to read on EtoBox.
What is YKL-40 as a novel biomarker related to white matter damage and cognitive impairment in patients with cerebral small vessel disease about?
YKL-40 is a novel neuroinflammatory marker associated with white matter damage and cognitive dysfunction. 110 CSVD patients, including 54 with mild cognitive impairment (CSVD-MCI), 56 with no cognitive impairment (CSVD-NCI), and 40 healthy controls (HCs) underwent multimodal magnetic resonance examination, serum YKL-40 level detection and cognitive function assessment to investigate the association between YKL-40 and white matter damage and cognitive impairment in cerebral small vessel disease (CSVD) patients. White matter hyperintensities volume was calculated using the Wisconsin White Matter Hyperintensity Segmentation Toolbox (W2MHS) for white matter macrostructural damage evaluation. For white matter microstructural damage evaluation, fractional anisotropy (FA) and mean diffusivity (MD) indices of the region of interest were analyzed based on diffusion tensor imaging (DTI) images using the Tract-Based Spatial Statistics (TBSS) pipeline. The serum YKL-40 level of CSVD was significantly higher than those of HCs, and the CSVD-MCI was higher than in HCs and CSVD-NCI. Furthermore, serum YKL-40 provided high diagnostic accuracy for CSVD and CSVD-MCI. The macroscopic and microstructur
Who reads YKL-40 as a novel biomarker related to white matter damage and cognitive impairment in patients with cerebral small vessel disease?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Wei Zhang; Xia Zhou; Jiabin Yin; Wenming Zhao; Chaojuan Huang; Cun Zhang; Ke Wan; Mingxu Li; Xiaoqun Zhu; Zhongwu Sun
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Neuroscience (Life Sciences)