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Can I read Activatable Nanomedicine for Overcoming Hypoxia-induced Resistance to Chemotherapy and Inhibiting Tumor Growth by Inducing Collaborative Apoptosis and Ferroptosis in Solid Tumors on EtoBox?
Activatable Nanomedicine for Overcoming Hypoxia-induced Resistance to Chemotherapy and Inhibiting Tumor Growth by Inducing Collaborative Apoptosis and Ferroptosis in Solid Tumors by Jingke Fu; Tao Li; Yangzi Yang; Liping Jiang; Wenhao Wang; Lingjie Fu; Yingchun Zhu; Yongqiang Hao is a Engineering article available to read on EtoBox.
What is Activatable Nanomedicine for Overcoming Hypoxia-induced Resistance to Chemotherapy and Inhibiting Tumor Growth by Inducing Collaborative Apoptosis and Ferroptosis in Solid Tumors about?
Hypoxia has been firmly correlated to the drug resistance of solid tumors. Alleviation of hypoxia by tumor reoxygenation is expected to sensitize the chemotherapy toward solid tumors. Alternatively, ferroptosis provides a therapeutic strategy to overcome apoptotic resistance and multidrug resistance of solid tumors, collaboratively strengthening the chemotherapy toward hypoxic tumors. Herein, an ultrasound (US)-activatable nanomedicine was developed for overcoming hypoxia-induced resistance to chemotherapy and efficiently inhibiting tumor growth by inducing sensitized apoptosis and collaborative ferroptosis of tumor cells. This nanomedicine was constructed by integrating ferrate and doxorubicin into biocompatible hollow mesoporous silica nanoplatforms, followed by assembling a solid-liquid phase-change material of n-heneicosane. The US-induced mild hyperthermia initiates the phase change of n-heneicosane, enabling US-activated co-release of ferrate and doxorubicin. Results reveal that the released ferrate effectively reacts with water as well as the over-expressed hydrogen peroxide and glutathione in tumor cells, achieving tumor-microenvironment-independent reoxygenation and glutat
Who reads Activatable Nanomedicine for Overcoming Hypoxia-induced Resistance to Chemotherapy and Inhibiting Tumor Growth by Inducing Collaborative Apoptosis and Ferroptosis in Solid Tumors?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Jingke Fu; Tao Li; Yangzi Yang; Liping Jiang; Wenhao Wang; Lingjie Fu; Yingchun Zhu; Yongqiang Hao
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Engineering (Physical Sciences)