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Mechanism of univalent antisperm antibody inhibition of fertilization in the sea urchin, Arbacia punctulata by Patricia M. Saling; William R. Eckberg; Charles B. Metz is a Environmental Science article available to read on EtoBox.

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## Abstract Univalent antisperm antibodies (IF ab) markedly inhibited the fertilizing capacity of sperm when tested on intact, dejellied, and “demembranated” __Arbacia punctulata__ eggs. Sperm motility and egg jelly penetration were not affected by IFab. Antifertilizin was excluded as the essential sperm antigen involved in the fertilization‐inhibiting action. Sperm pretreated with IF ab did not bind to the surfaces of either dejellied or demembranated eggs, whereas control globulin (CF ab) and seawater‐pretreated sperm bound to such eggs in high numbers. Electron microscopy showed that IF ab‐treated sperm failed to undergo the acrosome reaction. This excluded “bindin” as the essential antigen. Inhibition of fertilization by IF ab was reversed or bypassed by artificial induction of the acrosome reaction with ionophore A23187. It is concluded that univalent antisperm antibody treatment inhibits the fertilizing capacity of sperm by preventing a sperm‐egg interaction that results in the acrosome reaction; consequently, attachment of the sperm to the egg is prevented.

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Author

Patricia M. Saling; William R. Eckberg; Charles B. Metz

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-104X)

Published

1982

Language

EN

Field

Environmental Science (Life Sciences)