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What is HLA-B about?

The study investigates the role of HLA class I alleles, particularly HLA-B, in mediating CD8+ T-cell responses against HIV-1 in a cohort of 375 infected individuals from southern Africa. Results indicate that HLA-B alleles significantly influence HIV-specific T-cell activity and disease progression, with a greater association of viral load and CD4 counts with HLA-B compared to HLA-A or HLA-C. The findings suggest that HLA-B alleles exert a dominant effect on immune selection pressure against HIV, highlighti

Author

rohin athavale

Language

EN