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Immunohistochemical Evidence of Cytokine Networks During Progression of Human Melanocytic Lesions by Silvia Moretti; Cinzia Pinzi; Adelina Spallanzani; Emilio Berti; Alessandra Chiarugi; Sandra Mazzoli; Massimo Fabiani; Carlo Vallecchi; Meenhard Herlyn is a Medicine article available to read on EtoBox.

What is Immunohistochemical Evidence of Cytokine Networks During Progression of Human Melanocytic Lesions about?

Melanoma cells in culture express a variety of growth factors and cytokines and some of their autocrine and paracrine roles have been investigated. However, less information is available on the potential dynamic changes in expression of these molecules on cells during melanoma development and progression in situ. Using immunohistochemistry, we tested 40 nevi and primary and metastatic melanoma lesions for the expression of 10 growth factors and cytokines and the respective receptors representing 10 cell surface molecules. Nevi and thin (F 1 mm) primary melanomas showed little expression of ligands except weak reactivity of tumor necrosis factor-␣ (TNF-␣), transforming growth factor-␤ (TGF-␤), interleukin-8 (IL-8) and reactivity of TGF-␤R and c-kit. Marked up-regulation of growth factors, cytokines and receptor expression was observed in thick (G 1 mm) primary melanomas, which were stained with polyclonal or monoclonal antibodies (MAbs) for IL-1␣, IL-1␤, IL-6, IL-8, TNF-␣, TGF-␤, granulocyte-macrophage colony-stimulating factor (GM-CSF) and stem cell factor (SCF), but not IL-2. Metastases showed similar expression patterns except that SCF was absent. Co-expression of ligand and rece

Who reads Immunohistochemical Evidence of Cytokine Networks During Progression of Human Melanocytic Lesions?

Author

Silvia Moretti; Cinzia Pinzi; Adelina Spallanzani; Emilio Berti; Alessandra Chiarugi; Sandra Mazzoli; Massimo Fabiani; Carlo Vallecchi; Meenhard Herlyn

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1999

Language

EN

Field

Medicine (Health Sciences)