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Pain During Ice Water Test Distinguishes Clinical Bladder Hypersensitivity from Overactivity Disorders by Gaurav Mukerji; Janet Waters; Iain P Chessell; Chas Bountra; Sanjiv K Agarwal; Praveen Anand is a Medicine article available to read on EtoBox.

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## Background The Bladder cooling reflex (BCR) i.e. uninhibited detrusor contractions evoked by intravesical instillation of cold saline, is a segmental reflex believed to be triggered by menthol sensitive cold receptors in the bladder wall, with the afferent signals transmitted by C fibres. The BCR is a neonatal reflex that becomes suppressed by descending signals from higher centres at approximately the time when the child gains full voluntary control of voiding. It re-emerges in adults with neurogenic detrusor overactivity as a consequence of loss of central descending inhibition, resulting from conditions such as spinal cord injury or multiple sclerosis. We have recently shown an increase of nerve fibres expressing the cool and menthol receptor TRPM8 in both overactive (IDO) and painful bladder syndrome (PBS), but its functional significance is unknown. We have therefore studied the bladder cooling reflex and associated sensory symptoms in patients with PBS and overactivity disorders. ## Methods The BCR, elicited by ice water test (IWT) was performed in patients with painful bladder syndrome (PBS, n = 17), idiopathic detrusor overactivity (IDO, n = 22), neurogenic detrusor over

Who reads Pain During Ice Water Test Distinguishes Clinical Bladder Hypersensitivity from Overactivity Disorders?

Author

Gaurav Mukerji; Janet Waters; Iain P Chessell; Chas Bountra; Sanjiv K Agarwal; Praveen Anand

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC (ISSN 1471-2490)

Published

2006

Language

EN

Field

Medicine (Health Sciences)