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Relationship between actions of transforming growth factor (TGF)‐β and cell surface expression of its receptors in clonal osteoblastic cells by Yasuhiro Takeuchi; Seiji Fukumoto; Toshio Matsumoto is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Relationship between actions of transforming growth factor (TGF)‐β and cell surface expression of its receptors in clonal osteoblastic cells about?
Various osteoblastic cell lines were examined for the relationship between the presence of cell-surface transforming growth factor (TGF)-P receptors and the synthesis of matrix proteins with their responsiveness to TGF-P. Treatment with TGF-PI inhibited proliferation and stimulated proteoglycan and fibronectin synthesis in MC3T3-EI and M G 63 cells. The major proteoglycans synthesized by these cells were decorin and biglycan, and TGF-PI markedly stimulated the synthesis of decorin in MC3T3-El and of biglycan in M G 63 cells. SaOS 2 and UMR 106 cells synthesized barely detectable amounts of decorin or biglycan, and TGF-P1 did not stimulate the synthesis of these proteoglycans. In SaOS 2 cells, however, TGF-P1 enhanced fibronectin synthesis. TGF-P1 did not show any of these effects in UMR 106 cells. Receptor cross-linking studies revealed that only MC3T3-EI and M G 63 cells had both types I and II signal-transducing receptors for TGF-P in addition to betaglycan. SaOS 2 cells possessed type I but no type II receptor on the cell surface. In contrast, SaOS 2 as well as MC3T3-El and M G 63 cells expressed type I 1 receptor mRNA by Northern blot analysis, and cell lysates contained type I
Who reads Relationship between actions of transforming growth factor (TGF)‐β and cell surface expression of its receptors in clonal osteoblastic cells?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yasuhiro Takeuchi; Seiji Fukumoto; Toshio Matsumoto
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)
- Published
- 1995
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)