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Molecular Mechanisms of Environmental Exposures and Human Disease by Haotian Wu; Christina M. Eckhardt; Andrea A. Baccarelli is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Molecular Mechanisms of Environmental Exposures and Human Disease about?

A substantial proportion of disease risk for common complex dis orders is attributable to environmental exposures and pollutants. An appreciation of how environmental pollutants act on our cells to produce deleterious health effects has led to advances in our understanding of the molecular mechanisms underlying the pathogenesis of chronic diseases, including cancer and cardiovascular, neurodegenerative and respiratory diseases. Here, we discuss emerging research on the interplay of environmental pollutants with the human genome and epigenome. We review evidence showing the environmental impact on gene expression through epigenetic modifications, including DNA methylation, histone modification and noncoding RNAs. We also highlight recent studies that evaluate recently discovered molecular processes through which the environment can exert its effects, including extracellular vesicles, the epitranscriptome and the mitochondrial genome. Finally, we discuss current challenges when studying the exposome -the cumulative measure of environmental influences over the lifespan -and its integration into future environmental health research.

Who reads Molecular Mechanisms of Environmental Exposures and Human Disease?

Author

Haotian Wu; Christina M. Eckhardt; Andrea A. Baccarelli

Publisher

Nature Publishing Group; Springer Science and Business Media LLC (ISSN 1471-0056)

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)