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Specific inhibition of cyclooxygenase-2 with MK-0966 is associated with less gastroduodenal damage than either aspirin or ibuprofen by F. L. Lanza; M. F. Rack; T. J. Simon; H. Quan; J. A. Bolognese; M. E. Hoover; F. R. Wilson; S. E. Harper is a Medicine article available to read on EtoBox.

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## Background : Compared with currently available NSAIDs (which inhibit COX‐1 and COX‐2 isoforms of cyclooxy‐ genase), MK‐0966 (a specific COX‐2 inhibitor) is expected to cause less gastrointestinal toxicity. ## Aim : To compare the effect on the upper gastrointestinal mucosae of a high dose of MK‐0966 with that of conventional doses of ibuprofen and aspirin. ## Methods Healthy subjects (__n__ = 170; age range 18–54 years) with endoscopically normal gastric and duodenal mucosa were randomized to either MK‐0966 250 mg q.d. (__n__ = 51), ibuprofen 800 mg t.d.s. (__n__ = 51), aspirin 650 mg q.d.s. (__n__ = 17), or placebo (__n__ = 51) in this 7‐day, double‐blind, parallel‐group study. The mucosae were evaluated by endoscopy using a predefined scale; scores could range from 0 to 4. The primary end‐point was the percentage of subjects who developed a mucosal score ≥ 2 (i.e. the development of one or more erosions). To evaluate COX‐1 activity, serum thromboxane B~2~ levels were determined in a subset of the population. ## Results The percentage of subjects who developed a mucosal score ≥ 2 in the MK‐0966 group (12%) was significantly lower (__P__< 0.001) than that in the ibuprofen (71%)

Who reads Specific inhibition of cyclooxygenase-2 with MK-0966 is associated with less gastroduodenal damage than either aspirin or ibuprofen?

Author

F. L. Lanza; M. F. Rack; T. J. Simon; H. Quan; J. A. Bolognese; M. E. Hoover; F. R. Wilson; S. E. Harper

Publisher

John Wiley and Sons; Blackwell Publishing; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0269-2813)

Published

1999

Language

EN

Field

Medicine (Health Sciences)