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An injectable conductive Gelatin-PANI hydrogel system serves as a promising carrier to deliver BMSCs for Parkinson's disease treatment by Jinhua Xue; Yutong Liu; Mohammad Ali Darabi; Genghong Tu; Lu Huang; Li Ying; Bin Xiao; Yue Wu; Malcolm Xing; Lin Zhang; Lu Zhang is a Engineering article available to read on EtoBox.
What is An injectable conductive Gelatin-PANI hydrogel system serves as a promising carrier to deliver BMSCs for Parkinson's disease treatment about?
Parkinson's disease (PD) is a long-term neurodegenerative disorders that characterized by a progressive loss of dopaminergic neurons in substantia nigra pars compacta (SNc). Bone marrow stromal cells (BMSCs) are promising therapeutic agents for neurodegenerative disease due to their multipotent capacity. To promote the potential therapeutic effect of BMSCs on PD, we developed an injectable Gelatin-PANI hydrogels as a novel carrier for delivering BMSCs to the SNc region in mice with PD by stereotactic injection. Histology results showed that the BMSCs-loaded hydrogels lead to increased numbers of tyrosine hydroxylase positive (TH) dopaminergic neurons and fibers in the SNc and striatum, and increased expression of brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) in the SNc. Meanwhile, rotarod and open field evaluation demonstrated BMSCs-loaded hydrogels significantly improved the behavioral performance of PD mice. Importantly, BMSCs-loaded hydrogels imparted more sustained protective effects than BMSCs alone in PD mice. Overall, the current data indicate that the hydrogel serves as a promising carrier to deliver BMSCs to the SNc for the trea
Who reads An injectable conductive Gelatin-PANI hydrogel system serves as a promising carrier to deliver BMSCs for Parkinson's disease treatment?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Jinhua Xue; Yutong Liu; Mohammad Ali Darabi; Genghong Tu; Lu Huang; Li Ying; Bin Xiao; Yue Wu; Malcolm Xing; Lin Zhang; Lu Zhang
- Publisher
- Elsevier BV
- Published
- 2019
- Language
- EN
- Field
- Engineering (Physical Sciences)