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TGF-β/PI3K/AKT/mTOR/NF-kB pathway. Clinicopathological features in prostate cancer by Norelia Torrealba; Raúl Vera; Benito Fraile; Pilar Martínez-Onsurbe; Ricardo Paniagua; Mar Royuela is a Medicine article available to read on EtoBox.

What is TGF-β/PI3K/AKT/mTOR/NF-kB pathway. Clinicopathological features in prostate cancer about?

Prostate cancer is one of the most common cancers in the male population. The objective of this investigation was to study the relationship of components of transforming growth factor-B (TGF-β)/phosphoinositide-3-kinases (PI3K)/AKT/mammalian target of rapamycin (mTOR)/nuclear factor kappa B (NF-kB) transduction pathway with clinical-pathological markers. By immunohistochemical methods, we determined the expression of several factors [TGF-β, Transforming Growth Factor B Receptor I (TGFBRI), TGFBRII, PI3K, AKT-Ser, AKT-Thr, mTOR, p-mTOR, inhibitor kB kinase (IKK), pIKK, inhibitor kB (IkB), pIkB, NF-kBp50, and NF-kBp65]. To know their relationship with established classical markers (Preoperative serum prostate specific antigen, pathological tumor stage, clinical tumor stage, Gleason score, perineural invasion, node involvement, positive surgical margins, biochemical progression, and survival) and their importance in the prognosis of biochemical progression, Spearman test, survival analysis, Log-rang test, Kaplan-Meier curves, univariate and multivariate Cox proportional Hazard regression analyses were performed. Spearman analysis showed that there was at least one correlation between

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Author

Norelia Torrealba; Raúl Vera; Benito Fraile; Pilar Martínez-Onsurbe; Ricardo Paniagua; Mar Royuela

Publisher

Informa UK Limited

Published

2019

Language

EN

Field

Medicine (Health Sciences)