Can I read Biomarkers for Amyotrophic Lateral Sclerosis on EtoBox?

Biomarkers for Amyotrophic Lateral Sclerosis by Simon Witzel; Kristina Mayer; Patrick Oeckl is a Medicine article available to read on EtoBox.

What is Biomarkers for Amyotrophic Lateral Sclerosis about?

## Purpose of review: Amyotrophic lateral sclerosis (als) is an incurable, devastating neurodegenerative disease. still, the diagnosis is mainly based on clinical symptoms, and the treatment options are strongly limited. however, the pipeline of potential treatments currently tested in clinical trials is promising. this review will discuss developments in als biomarker research and applications within the last 2 years and suggest future directions and needs. ## Recent findings: The diagnostic and prognostic utility of neurofilaments, a general marker for axoneuronal degeneration, has been confirmed by further studies in patients with als, and neurofilaments are finding their way into routine diagnostic and clinical trials. additionally, there have been advancements in developing and implementing disease-specific biomarkers, especially in patients with a genetic variant, such as sod1 or c9orf72 . here, biomarkers have already been used as target markers and outcome parameters for novel treatment approaches. in addition, several novel biomarkers have shown encouraging results but should be discussed in the context of their early stage of assay and clinical establishment. ## Summary:

Who reads Biomarkers for Amyotrophic Lateral Sclerosis?

Author

Simon Witzel; Kristina Mayer; Patrick Oeckl

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2022

Language

EN

Field

Medicine (Health Sciences)