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Effectiveness of Piracetam in Cortical Myoclonus by P. Brown; M. J. Steiger; P. D. Thompson; J. C. Rothwell; B. L. Day; M. Salama; T. Waegemans; Prof. C. D. Marsden is a Medicine article available to read on EtoBox.

What is Effectiveness of Piracetam in Cortical Myoclonus about?

## Abstract Twenty‐one patients with disabling spontaneous, reflex, or action myoclonus due to various causes, who had shown apparent clinical improvement on introduction of piracetam, entered a placebo‐controlled double‐blind crossover trial of piracetam (2.4– 16.8 g daily). All but one patient had electrophysiological evidence of cortical myoclonus. Patients were randomly allocated to a 14‐ day course of piracetam followed by identical placebo, or placebo followed by piracetam. Nineteen patients received piracetam/placebo in addition to their routine antimyoclonic treatment (carbamazepine, clonazepam, phenytoin, primidone, sodium valproate, or tryptophan plus isocarboxazid, alone or in combination) and two received piracetam/placebo as monotherapy. All patients were rated at the end of each treatment phase using stimulus sensitivity, motor, writing, functional disability, global assessment, and visual analogue scales. Ten of the 21 patients had to be rescued from the placebo phase of the trial because of a severe and intolerable exacerbation of their myoclonus. No patients required rescue from the piracetam phase of the double‐blind trial. When the 21 patients were considered tog

Who reads Effectiveness of Piracetam in Cortical Myoclonus?

Author

P. Brown; M. J. Steiger; P. D. Thompson; J. C. Rothwell; B. L. Day; M. Salama; T. Waegemans; Prof. C. D. Marsden

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)

Published

1993

Language

EN

Field

Medicine (Health Sciences)