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Highly sensitive interfaces of graphene electrical-electrochemical vertical devices for on drop atto-molar DNA detection by Mattioli, Isabela A.; Hassan, Ayaz; Sanches, Natalia M.; Vieira, Nirton C.S.; Crespilho, Frank N. is a Engineering article available to read on EtoBox.
What is Highly sensitive interfaces of graphene electrical-electrochemical vertical devices for on drop atto-molar DNA detection about?
The development of novel high-sensitivity DNA-based biosensors is beneficial, as these devices have applications in the identification of genetic risk factors, medical diagnostics, and environmental monitoring. Herein, we report on the first robust device capable of detecting DNA on a microliter drop with a zepto-molar (10) concentration. To accomplish this, we engineered an electrical-electrochemical vertical device (EEVD) that comprises a novel drain and source terminal in a short-circuited configuration, paired with an ideal non-polarizable reference electrode. Vertical electron transfer occurs perpendicularly to the graphene plane, while the electronic current flows through the graphene van der Waals (vdW) heterojunctions. Ferrocene adsorbed on graphene was strategically chosen as the vdW heterojunction redox component. Charge carrier insertion into the graphene makes the EEVD 10 times more sensitive than traditional graphene field-effect transistors. Interfacial potential changes were measured for single-stranded DNA detection with an unprecedented zepto-molar limit of detection.
Who reads Highly sensitive interfaces of graphene electrical-electrochemical vertical devices for on drop atto-molar DNA detection?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Mattioli, Isabela A.; Hassan, Ayaz; Sanches, Natalia M.; Vieira, Nirton C.S.; Crespilho, Frank N.
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0956-5663)
- Published
- 2021
- Language
- EN
- Field
- Engineering (Physical Sciences)