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Investigation of New Co‐factors in 49 Patients with Pyoderma Gangrenosum by Philipp Al Ghazal; Andreas Körber; Joachim Klode; Joachim Dissemond is a Medicine article available to read on EtoBox.

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## Summary __Background:__ Pyoderma gangrenosum is a rare, destructive, ulcerative neutrophilic dermatosis of unknown origin that has been investigated insufficiently in clinical studies. According to current textbooks, it is often associated with chronic inflammatory bowel diseases or other autoimmune disorders. __Patients and methods:__ We retrospectively analyzed data from 49 patients with pyoderma gangrenosum. __Results:__ Our results showed that although only 6.1 % of patients had chronic inflammatory bowel disease, 22.4 % patients had a malignancy, 18.4 % had chronic renal insufficiency, and 42.8 % had anemia. A potentially relevant aspect that has received little attention is an association with endocrine diseases in 38.8 % of patients. 28.6 % of patients had diabetes. Given that 32.6 % of patients were obese, a potential association with metabolic syndrome may be considered as a possible new risk factor for pyoderma gangrenosum. __Conclusions:__ The clinical data from the present study are insufficient for drawing any firm conclusions. We did, however, observe an association between pyoderma gangrenosum and certain as yet unreported co‐factors, in particular metabolic syndr

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Author

Philipp Al Ghazal; Andreas Körber; Joachim Klode; Joachim Dissemond

Publisher

Wiley

Published

2011

Language

EN

Field

Medicine (Health Sciences)