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Can I read Role of Branched-chain Amino Acid Metabolism in Tumor Development and Progression on EtoBox?
Role of Branched-chain Amino Acid Metabolism in Tumor Development and Progression by Min Kyu Jung; Akinkunmi Paul Okekunle; Jung Eun Lee; Mi Kyung Sung; Yun Jeong Lim is a Medicine article available to read on EtoBox.
What is Role of Branched-chain Amino Acid Metabolism in Tumor Development and Progression about?
Branched-chain amino acids (BCAAs), isoleucine, leucine and valine, are essential amino acids with vital roles in protein synthesis and energy production. We reviewed the fundamentals of BCAA metabolism in advanced cancer patients. BCAAs and various catabolic products act as signalling molecules, which activate mechanisms ranging from protein synthesis to insulin secretion. Recently, BCAA metabolism has been suggested to contribute to cancer progression. Of particular interest is the modulation of the mTOR activity by BCAAs. There are likely multiple pathways involved in BCAA metabolism implicated in carcinogenesis. Understanding the mechanism(s) underlying altered BCAAs metabolism will significantly advance the current understanding of nutrient involvement in carcinogenesis and direct future studies to unravel the significance of BCCA metabolites in tumor development and progression.
Who reads Role of Branched-chain Amino Acid Metabolism in Tumor Development and Progression?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Min Kyu Jung; Akinkunmi Paul Okekunle; Jung Eun Lee; Mi Kyung Sung; Yun Jeong Lim
- Publisher
- Korean Society of Cancer Prevention
- Published
- 2021
- Language
- EN
- Field
- Medicine (Life Sciences)