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Can I read The Efficacy and Safety of Radical Prostatectomy and Radiotherapy in High-risk Prostate Cancer: a Systematic Review and Meta-analysis on EtoBox?
The Efficacy and Safety of Radical Prostatectomy and Radiotherapy in High-risk Prostate Cancer: a Systematic Review and Meta-analysis by Wang, Zhipeng; Ni, Yuchao; Chen, Junru; Sun, Guangxi; Zhang, Xingming; Zhao, Jinge; Zhu, Xudong; Zhang, Haoran; Zhu, Sha; Dai, Jindong; Shen, Pengfei; Zeng, Hao is a Medicine article available to read on EtoBox.
What is The Efficacy and Safety of Radical Prostatectomy and Radiotherapy in High-risk Prostate Cancer: a Systematic Review and Meta-analysis about?
## Background The optimal treatment for patients with high-risk prostate cancer (PCa) remains a debate and selection of patients to receive proper therapy is still an unsettled question. This systematic review was conducted to compare the effectiveness of prostatectomy (RP) and radiotherapy (RT) in patients with high-risk PCa and to select candidates for optimal treatment. ## Methods PubMed, EMBASE, and Cochrane Central Register of Controlled Trials were searched for eligible studies. We extracted hazard ratios (HRs) and 95% confidence interval (CI) of all included studies. The primary outcomes were overall survival (OS) and cancer-specific survival (CSS); the secondary outcomes were biochemical recurrence-free survival (BRFS), metastasis-free survival (MFS) and clinical recurrence-free survival (CRFS). The meta-analysis was performed using Review Manager 5.3. Subgroup analyses were conducted according to Gleason score (GS), T stage and RT types. Quality of life (QoL) was compared with these two treatments. ## Results A total of 25 studies were included in this meta-analysis. Overall, RP showed more survival benefits than RT on CSS (__P__ = 0.003) and OS (__P__ = 0.002); while RT w
Who reads The Efficacy and Safety of Radical Prostatectomy and Radiotherapy in High-risk Prostate Cancer: a Systematic Review and Meta-analysis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Wang, Zhipeng; Ni, Yuchao; Chen, Junru; Sun, Guangxi; Zhang, Xingming; Zhao, Jinge; Zhu, Xudong; Zhang, Haoran; Zhu, Sha; Dai, Jindong; Shen, Pengfei; Zeng, Hao
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2003-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1477-7819)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)