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Can I read Biomimeting ultra-small lipid nanoconstructs for glioblastoma treatment: A computationally guided experimental approach on EtoBox?
Biomimeting ultra-small lipid nanoconstructs for glioblastoma treatment: A computationally guided experimental approach by Maria Mendes; João Basso; Jessica Silva; Tânia Cova; João Sousa; Alberto Pais; Carla Vitorino is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.
What is Biomimeting ultra-small lipid nanoconstructs for glioblastoma treatment: A computationally guided experimental approach about?
Ultra-small nanostructured lipid carriers (usNLCs) are stable, biocompatible and biodegradable colloidal systems, claiming a broad set of advanced features suitable for cancer drug delivery. To unleash their potential in glioblastoma research and therapy, we have developed an usNLC prototype able to co-encapsulate atorvastatin calcium and curcumin, as repurposed drugs previously screened from molecular dynamics simulations. The novelty not only relies on the drug repositioning approach, but also on a robust computational methodology utilized for formulation optimization, under the umbrella of multivariate analysis and full factorial designs. A coating procedure with red blood cell membranes is ultimately hypothesized, aiming at integrating the biomimetic concept into usNLCs for glioblastoma therapeutics. The formulation composition and process parameters, that demonstrated a high-risk level for the final quality and performance of the usNLCs, include the solid:liquid lipid ratio, type and concentration of liquid lipids and surfactants, along with the type of production method. Particles with an average diameter of ca. 50 nm, and a polydispersity index lower than 0.3 were produced,
Who reads Biomimeting ultra-small lipid nanoconstructs for glioblastoma treatment: A computationally guided experimental approach?
It is typically read by researchers, students, and practitioners in Pharmacology, Toxicology and Pharmaceutics.
- Author
- Maria Mendes; João Basso; Jessica Silva; Tânia Cova; João Sousa; Alberto Pais; Carla Vitorino
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Pharmacology, Toxicology and Pharmaceutics (Life Sciences)