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Can I read Coenzyme Q10 supplementation mitigates piroxicam-induced oxidative injury and apoptotic pathways in the stomach, liver, and kidney on EtoBox?
Coenzyme Q10 supplementation mitigates piroxicam-induced oxidative injury and apoptotic pathways in the stomach, liver, and kidney by Ahmed Abdeen; Afaf Abdelkader; Dina Elgazzar; Mohamed Aboubakr; Omnia A. Abdulah; Khaled Shoghy; Mohamed Abdel-Daim; Hamed A. El-Serehy; Agnieszka Najda; Amany El-Mleeh is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Coenzyme Q10 supplementation mitigates piroxicam-induced oxidative injury and apoptotic pathways in the stomach, liver, and kidney about?
Piroxicam (PM) is an oxicam-NSAID commonly recommended for various pain and associated inflammatory disorders. However, it is reported to have a gastric and hepato-renal toxic effect. Therefore, the current research was planned to investigate the possible mechanisms behind the mitigating action of the coenzyme (CoQ10), a natural, free radical scavenger, against PM tissue injury. Rats were assigned to five equal groups; Control, CoQ10 (10 mg/kg, orally), PM (7 mg/kg, i.p.), CoQ + PM L, and CoQ + PM H group. After 28 days, PM provoked severe gastric ulceration and marked liver and kidney damage indicated by an elevated gastric ulcer index and considerable alteration in liver and kidney biochemical tests. The toxic effects might be attributed to mitochondrial dysfunction and excess generation of reactive oxygen species (ROS), as indicated by enhanced malondialdehyde (MDA) levels along with decreased reduced-glutathione (GSH) levels and catalase (CAT) activity. Apoptotic cell death also was demonstrated by increased regulation of activated caspase-3 in the stomach, liver, and kidney tissues. Interestingly, external supplementation of CoQ10 attenuated the PM-inflicted deleterious oxidat
Who reads Coenzyme Q10 supplementation mitigates piroxicam-induced oxidative injury and apoptotic pathways in the stomach, liver, and kidney?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ahmed Abdeen; Afaf Abdelkader; Dina Elgazzar; Mohamed Aboubakr; Omnia A. Abdulah; Khaled Shoghy; Mohamed Abdel-Daim; Hamed A. El-Serehy; Agnieszka Najda; Amany El-Mleeh
- Publisher
- Elsevier Science; Elsevier ; Elsevier Masson; Elsevier BV (ISSN 0753-3322)
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)