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Transcriptomic analysis reveals the promotion of lymph node metastasis by Helicobacter pylori infection via upregulating chemokine (C-X-C motif) receptor 2 expression in gastric carcinoma by Lang Zha; Xiong Guo; Xiaolong Liang; Yuedong Chen; Deyong Gan; Wenwen Li; Ziwei Wang; Hongyu Zhang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Transcriptomic analysis reveals the promotion of lymph node metastasis by Helicobacter pylori infection via upregulating chemokine (C-X-C motif) receptor 2 expression in gastric carcinoma about?

Gastric carcinoma (GC) progression is mainly caused by local aggression and lymph node metastasis. However, some patients with early T-stage disease have lymph node metastasis, whereas some patients with late T-stage disease do not have lymph node metastasis, which indicates that invasion and metastasis are not always sequential in some GC patients. In the present study, the data of 101 GC cases were acquired from TCGA and divided into T-late-N-negative and T-early-N-positive groups according to pathological stages. A total of 338 genes were identified as differential genes between the T-late-N-negative and T-early-N-positive groups. GSEA showed that epithelial cell signaling in the __Helicobacter pylori__ (__HP__) infection pathway was enriched in the T-early-N-positive group. MB staining indicated that the __HP__ infection rate was 63% (39/62) in N-positive patients compared to 42% (16/38) in N-negative patients. To investigate the potential mechanism, we focused on the gene chemokine (C-X-C motif) receptor 2 (CXCR2), which was not only clustered in the gene set of epithelial cells signaling in the __HP__ infection pathway but also significantly upregulated in T-early-N-positive

Who reads Transcriptomic analysis reveals the promotion of lymph node metastasis by Helicobacter pylori infection via upregulating chemokine (C-X-C motif) receptor 2 expression in gastric carcinoma?

Author

Lang Zha; Xiong Guo; Xiaolong Liang; Yuedong Chen; Deyong Gan; Wenwen Li; Ziwei Wang; Hongyu Zhang

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)