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Fe-TCPP@CS nanoparticles as photodynamic and photothermal agents for efficient antimicrobial therapy by Yufeng Zhang; Jing Ma; Dianwei Wang; Caina Xu; Shu Sheng; Jianfeng Cheng; Changjiang Bao; Yanhui Li; Huayu Tian is a Engineering article available to read on EtoBox.

What is Fe-TCPP@CS nanoparticles as photodynamic and photothermal agents for efficient antimicrobial therapy about?

Traditional antimicrobial therapies always rely on antibiotics, which have led to the overuse of antibiotics and caused the emergence of multidrug-resistant (MDR) bacteria in recent years. In this study, an efficient and broad-spectrum antimicrobial system based on chitosan (CS)-encapsulated multifunctional metal-organic nanoparticles (Fe-TCPP@CS NPs) was constructed to integrate the electrostatic targeting property and photodynamic and photothermal antimicrobial therapies. Tetrakis (4-carboxyphenyl) porphyrin (TCPP) coordinated with FeO clusters to form nanoparticles, FeO clusters enabled low-temperature photothermal therapy as well as avoiding the porphyrins self-aggregation to ensure the singlet oxygen yield under irradiation, and CS as the outer layer covered on Fe-TCPP nanoparticles could improve the dispersibility in aqueous solution and enhance the electrostatic binding with bacterial cell membranes to improve the antibacterial activities. After simple synthesis, we successfully obtained ideal and biocompatible multifunctional nanoparticles and verified their antimicrobial properties. Under light irradiation, Fe-TCPP@CS NPs could produce enough ROS and heat to kill S. aureus

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Author

Yufeng Zhang; Jing Ma; Dianwei Wang; Caina Xu; Shu Sheng; Jianfeng Cheng; Changjiang Bao; Yanhui Li; Huayu Tian

Published

2020

Language

EN

Field

Engineering (Physical Sciences)