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Synthesis of α-Hydroxy-methylenebisphos-phonates by the Microwave-assisted Reaction of α-Oxophosphonates and Dialkyl Phosphites Under Solventless Conditions by Alajos Grün; István Gábor Molnár; Béla Bertók; István Greiner; György Keglevich is a Chemistry article available to read on EtoBox.

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## Abstract The synthesis of hydroxy‐methylenebisphosphonates (**2a–c**) by the addition of dialkyl phosphite to the carbonyl group of the corresponding α‐oxophosphonate (**1a–c**) was studied under microwave irradiation (MW) and solventless conditions in the presence of dialkylamine as the catalyst. After optimization, products **2a** and **2b** were obtained selectively and in good yields avoiding the formation of the phosphonate‐phosphate by‐product (**3a** and **3b**) that is the result of a rearrangement. The MW‐assisted synthesis of hydroxybisphosphonates (**2a** and **2b**) offers complete conversions and a chemoselectivity of 100% as compared to the not so efficient thermal reaction. At the same time, the phenyl‐substituted methylenebisphosphonate **2c** could be obtained in only 75% selectivity. © 2009 Wiley Periodicals, Inc. Heteroatom Chem 20:350–354, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20558

Who reads Synthesis of α-Hydroxy-methylenebisphos-phonates by the Microwave-assisted Reaction of α-Oxophosphonates and Dialkyl Phosphites Under Solventless Conditions?

Author

Alajos Grün; István Gábor Molnár; Béla Bertók; István Greiner; György Keglevich

Publisher

John Wiley and Sons; Hindawi Limited; John Wiley & Sons Inc.; Wiley (ISSN 1042-7163)

Published

2009

Language

EN

Field

Chemistry (Physical Sciences)