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Regioselective synthesis of peptidic derivatives and glycolamidic esters of Methotrexate by Cédric Castex; Christophe Lalanne; Patrick Mouchet; Marc Lemaire; Roger Lahana is a Chemistry article available to read on EtoBox.

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Convenient methods for regioselective syntheses of Methotrexate peptidic conjugates are described. Solid phase synthesis for derivatives of Methotrexate containing an amide bond has been applied and showed higher efficiency than liquid phase synthesis. Synthetic pathways for regioselective preparation of Glycolamidic ester derivatives of Methotrexate were also developed using 4-amino-4-deoxy-N 10methylpteroic acid as starting material. These ester bonds were obtained either in solution or by using a combined liquid and solid phase synthesis.

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Author

Cédric Castex; Christophe Lalanne; Patrick Mouchet; Marc Lemaire; Roger Lahana

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4020)

Published

2005

Language

EN

Field

Chemistry (Physical Sciences)