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Increased collagenase and dipeptidyl peptidase I activity in leucocytes from healthy elderly people by L LLORENTE; Y RICHAUD-PATIN; A DÍAZ-BORJÓN; J JAKEZ-OCAMPO; C ALVARADO-DE LA BARRERA is a Immunology and Microbiology article available to read on EtoBox.

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## Abstract The incidence of infectious diseases increases with ageing. The enzymatic activity of leucocytes may have a relevant role in the morbidity and mortality due to infections in the elderly. In this study we have compared the activity of enzymes involved in the inflammatory response in leucocytes from young and elderly women. A total of 35 healthy females was studied, 20 volunteers aged 78–98 years (mean 89.1 years) and 15 young controls aged 19–34 years (mean 26 years). All of them were in good clinical condition, without any acute or chronic disease. Intracellular enzyme activity was analysed by flow cytometry in leucocytes from young and elderly women. The enzyme substrates employed were for oxidative burst, l-aminopeptidase, collagenase, cathepsin B, C, D and, G and dipeptidyl peptidase I. The intracellular enzyme activity assessed by flow cytometry in leucocytes from young and elderly women was similar, as far as oxidative burst, l-aminopeptidase, cathepsin B, C, D and G are concerned. An increased collagenase activity was detected in granulocytes from elders. The mean fluorescence channels for this enzyme corresponded to 86 ± 23 and 60 ± 15 in cells from elders and co

Who reads Increased collagenase and dipeptidyl peptidase I activity in leucocytes from healthy elderly people?

Author

L LLORENTE; Y RICHAUD-PATIN; A DÍAZ-BORJÓN; J JAKEZ-OCAMPO; C ALVARADO-DE LA BARRERA

Publisher

Oxford University Press (OUP)

Published

1999

Language

EN

Field

Immunology and Microbiology (Life Sciences)