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Microglial Response to Light‐induced Photoreceptor Degeneration in the Mouse Retina by Ana M. Santos; David Martín‐Oliva; Rosa M. Ferrer‐Martín; Mohamed Tassi; Ruth Calvente; Ana Sierra; Maria‐Carmen Carrasco; José L. Marín‐Teva; Julio Navascués; Miguel A. Cuadros is a Neuroscience article available to read on EtoBox.
What is Microglial Response to Light‐induced Photoreceptor Degeneration in the Mouse Retina about?
## Abstract The microglial response elicited by degeneration of retinal photoreceptor cells was characterized in BALB/c mice exposed to bright light for 7 hours and then kept in complete darkness for survival times ranging from 0 hours to 10 days. Photodegeneration resulted in extensive cell death in the retina, mainly in the outer nuclear layer (ONL), where the photoreceptor nuclei are located. Specific immunolabeling of microglial cells with anti‐CD11b, anti‐CD45, anti‐F4/80, anti‐SRA, and anti‐CD68 antibodies revealed that microglial cells were activated in light‐exposed retinas. They migrated to the ONL, changed their morphology, becoming rounded cells with short and thick processes, and, finally, showed immunophenotypic changes. Specifically, retinal microglia began to strongly express antigens recognized by anti‐CD11b, anti‐CD45, and anti‐F4/80, coincident with cell degeneration. In contrast, upregulation of the antigen recognized by anti‐SRA was not detected by immunocytochemistry until 6 hours after light exposure. Differences were also observed at 10 days after light exposure: CD11b, CD45, and F4/80 continued to be strongly expressed in retinal microglia, whereas the expre
Who reads Microglial Response to Light‐induced Photoreceptor Degeneration in the Mouse Retina?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Ana M. Santos; David Martín‐Oliva; Rosa M. Ferrer‐Martín; Mohamed Tassi; Ruth Calvente; Ana Sierra; Maria‐Carmen Carrasco; José L. Marín‐Teva; Julio Navascués; Miguel A. Cuadros
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)
- Published
- 2009
- Language
- EN
- Field
- Neuroscience (Life Sciences)