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Can I read Dedifferentiation Maintains Melanocyte Stem Cells in a Dynamic Niche on EtoBox?
Dedifferentiation Maintains Melanocyte Stem Cells in a Dynamic Niche by Qi Sun; Wendy Lee; Hai Hu; Tatsuya Ogawa; Sophie De Leon; Ioanna Katehis; Chae Ho Lim; Makoto Takeo; Michael Cammer; M. Mark Taketo; Denise L. Gay; Sarah E. Millar; Mayumi Ito is a Physics and Astronomy article available to read on EtoBox.
What is Dedifferentiation Maintains Melanocyte Stem Cells in a Dynamic Niche about?
For unknow reasons, the melanocyte stem cell (McSC) system fails earlier than other adult stem cell populations^1^, which leads to hair greying in most humans and mice^2,3^. Current dogma states that McSCs are reserved in an undifferentiated state in the hair follicle niche, physically segregated from differentiated progeny that migrate away following cues of regenerative stimuli^4–8^. Here we show that most McSCs toggle between transit-amplifying and stem cell states for both self-renewal and generation of mature progeny, a mechanism fundamentally distinct from those of other self-renewing systems. Live imaging and single-cell RNA sequencing revealed that McSCs are mobile, translocating between hair follicle stem cell and transit-amplifying compartments where they reversibly enter distinct differentiation states governed by local microenvironmental cues (for example, WNT). Long-term lineage tracing demonstrated that the McSC system is maintained by reverted McSCs rather than by reserved stem cells inherently exempt from reversible changes. During ageing, there is accumulation of stranded McSCs that do not contribute to the regeneration of melanocyte progeny. These results identify
Who reads Dedifferentiation Maintains Melanocyte Stem Cells in a Dynamic Niche?
It is typically read by researchers, students, and practitioners in Physics and Astronomy.
- Author
- Qi Sun; Wendy Lee; Hai Hu; Tatsuya Ogawa; Sophie De Leon; Ioanna Katehis; Chae Ho Lim; Makoto Takeo; Michael Cammer; M. Mark Taketo; Denise L. Gay; Sarah E. Millar; Mayumi Ito
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Physics and Astronomy (Physical Sciences)